Eurycomanone

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Eurycomanone, a high-purity natural quassinoid isolated from the root of Eurycoma longifolia (Tongkat Ali / Long Jack) through controlled food-grade solvent extraction, column chromatography and recrystallization. Our production workflow isolates and standardizes eurycomanone, the principal bioactive quassinoid marker of Tongkat Ali, delivering consistent ≥98% HPLC material for male-vitality and adaptogen supplement formulators, sports-nutrition developers and pharmaceutical research teams worldwide.

Why Choose Noksoul Eurycomanone

• Principal Quassinoid Marker.  Eurycomanone (CAS 84633-29-4) is the most abundant and best-characterized quassinoid in Tongkat Ali root, with documented male-vitality, adaptogen / anti-fatigue and antimalarial activity. It is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance for Tongkat Ali–positioned products.
• Controlled Purification Preserving Quassinoid Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and recrystallization under controlled conditions, preserving the highly oxygenated quassinoid structure while removing co-extracted glycosaponins and unrelated impurities.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for eurycomanone purity (≥98%), alongside profiling of related quassinoid impurities such as eurycomanol and epoxyeurycomanone. Multi-analyte documentation gives formulators full traceability to support regulatory filing and label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Eurycomanone

Botanical Source and Biological Composition

Eurycomanone (CAS 84633-29-4, C20H24O9, MW 408.40 g/mol) is the principal bioactive quassinoid naturally accumulated in the root of Eurycoma longifolia (Tongkat Ali / Long Jack), a traditional Southeast Asian medicinal plant. As a highly oxygenated nortriterpenoid quassinoid, eurycomanone is the characteristic marker compound used to standardize Tongkat Ali root extracts (typically 0.8–3% eurycomanone in commercial extracts). It is widely studied for male-vitality and hormonal support, adaptogen / anti-fatigue effects, and antimalarial and antiproliferative activity. These properties underpin its broad use in men's-health, sports-nutrition and adaptogen nutraceuticals, as well as in pharmaceutical and natural-product research.

Standardized Eurycomanone vs. Crude Tongkat Ali Root Powder

Crude Tongkat Ali root powder contains eurycomanone alongside other quassinoids (eurycomanol, epoxyeurycomanone), glycosaponins, alkaloids and woody fibre; eurycomanone content varies with root age, origin and extraction process. Standardized eurycomanone produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control, reference-standard use and reliable batch-to-batch reproducibility for finished products.

Production Process

Incoming Eurycoma longifolia root raw material is inspected for botanical identity, initial quassinoid content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried Tongkat Ali root chips are cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated root undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize quassinoid components, maximizing eurycomanone yield while limiting co-extraction of glycosaponins and woody pigments.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude quassinoid fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating eurycomanone from other co-extracted quassinoids, glycosaponins and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified eurycomanone solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for eurycomanone content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Male-Vitality and Hormonal Support.  Eurycomanone is the principal marker compound associated with Tongkat Ali's traditional use for male vitality, stamina and hormonal-balance support.
• Adaptogen and Anti-Fatigue Activity.  Documented adaptogen-like effects support physical stamina, exercise recovery and everyday fatigue-resistance positioning.
• Sports-Nutrition and Recovery Support.  Widely used in men's health and sports-nutrition formulations for strength, lean-mass and recovery support.
• Antioxidant and Anti-Inflammatory Activity.  Quassinoid antioxidant and anti-inflammatory activity supports general wellness and immune-support formulations.
• Pharma and Natural-Product Research.  Eurycomanone is widely studied for antimalarial, antiproliferative and other pharmacological mechanisms, making it a valuable research-grade reference standard.

Applications

• Men's-Health and Vitality Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support men's-vitality, hormonal-balance and Tongkat Ali–positioned supplement products.
• Sports-Nutrition and Adaptogen Products.  Used in pre-workout, endurance, recovery and adaptogen / stress-support finished goods.
• Standardized Tongkat Ali Extract Marker.  Serves as the reference-standard marker for QC of standardized Tongkat Ali root extracts (typically standardized to 1–3% eurycomanone by HPLC).
• Pharmaceutical and Scientific Research.  ≥98% HPLC-grade eurycomanone supplied for in-vitro and in-vivo pharmacological research, natural-product chemistry and quassinoid mechanism studies.

Contact Noksoul for Eurycomanone Supply

Noksoul supplies eurycomanone with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.