Kaempferol

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Kaempferol, a high-purity natural flavonol isolated from Sophora japonica fruit (pagoda tree pod) through controlled food-grade solvent extraction, column chromatography and low-temperature recrystallization. Our production workflow isolates and standardizes kaempferol, the primary bioactive flavonol aglycone, delivering consistent ≥98% HPLC material for antioxidant supplement formulators, anti-aging and brightening cosmetic developers, nutraceutical manufacturers and scientific research teams worldwide.

Why Choose Noksoul Kaempferol

• Natural Isolated Flavonol Active.  Kaempferol (CAS 520-18-3) is a well-characterized plant-derived flavonol with defined free-radical-scavenging, anti-inflammatory, tyrosinase-inhibiting and collagen-supporting activity. Sourced from Sophora japonica fruit, it is delivered as a single standardized ≥98% active ingredient rather than variable-content crude botanical powder, simplifying dose design and label-claim compliance.
• Gentle Low-Temperature Purification for Bioactivity Preservation.  Our manufacturing applies optimized food-grade solvent extraction, chromatographic separation and low-temperature recrystallization. This route avoids aggressive thermal degradation that can impair kaempferol molecular integrity and flavonol bioactivity, compared with harsh high-temperature processing that generates higher levels of related-substance impurities.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for kaempferol purity (≥98%), alongside profiling of related flavonoid impurities such as quercetin and rutin. Multi-analyte documentation gives formulators full ingredient traceability to support regulatory filing and finished-product label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvent levels in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final yellow crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical food-safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials already serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Kaempferol

Botanical Source and Biological Composition

Kaempferol (CAS 520-18-3, C15H10O6, MW 286.24 g/mol) is a flavonol-class polyphenol naturally accumulated in the fruit of Sophora japonica. As a potent antioxidant, it scavenges intracellular reactive oxygen species (ROS) and inhibits lipid peroxidation, helping delay cellular oxidative aging and protect skin and systemic tissues. It also exhibits well-documented anti-inflammatory activity — inhibiting the release of NO, TNF-α and IL-6 — together with tyrosinase-inhibiting and collagen-synthesis-promoting effects that underpin its use in mature-skin, brightening and anti-aging cosmetic formulations, as well as in antioxidant, bone-health and cardiometabolic dietary supplements.

Kaempferol Extract vs. Crude Sophora japonica Powder

Crude Sophora japonica powder is mechanically milled dried plant material containing kaempferol alongside large amounts of fibre, polysaccharides and other flavonoids (including rutin and quercetin glycosides); kaempferol content varies widely with growing season, harvest time and raw-material origin. Kaempferol produced via extraction, chromatography and recrystallization is highly enriched and standardized to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished dietary-supplement, cosmetic and nutricosmetic products.

Production Process

Incoming Sophora japonica fruit raw material is inspected for botanical identity, initial marker-compound content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried Sophora japonica fruit is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated plant material undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize flavonoid components, maximizing kaempferol yield while limiting co-extraction of high-molecular-weight plant impurities.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude flavonoid fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating kaempferol from other co-extracted flavonoids (e.g. quercetin), sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified kaempferol solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline yellow solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed by HPLC for kaempferol content, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Potent Antioxidant and Free-Radical Defence.  Kaempferol scavenges intracellular reactive oxygen species (ROS) and inhibits lipid peroxidation, significantly delaying cellular oxidative aging. Supports finished products positioned for daily oxidative-stress defence, age-related wellness and skin health.
• Anti-Inflammatory and Skin-Sensitivity Support.  Inhibits the release of inflammatory factors (NO, TNF-α, IL-6), helping alleviate chronic low-grade inflammation and improve sensitive-skin conditions such as acne-prone and irritated dermatitis.
• Skin Brightening, Collagen Support and Anti-Aging.  Inhibits tyrosinase activity to reduce melanin formation, supports collagen synthesis and helps maintain skin elasticity and firmness. A versatile active for mature-skin serums, creams, lotions, eye-care products and beauty-from-within nutricosmetics.
• Bone and Metabolic Wellness.  Modulates bone-remodelling pathways by inhibiting osteoclast activity, supporting maintenance of healthy bone mineral density; also shows potential regulatory effects on lipid metabolism and blood-glucose control.
• Research and Pharmaceutical Intermediates.  The defined flavonol structure and broad multi-target activity make high-purity kaempferol a reference compound widely used in cell biology, pharmacology and pharmaceutical intermediate research.

Applications

• Antioxidant and Daily-Health Dietary Supplements.  Supplied for hard capsules, tablets and soft-gel nutraceutical formats. ≥98% HPLC purity and full regulatory documentation support antioxidant-complex and general-health supplement positioning.
• Bone-Health and Metabolic Nutraceutical Blends.  Combined with calcium, vitamin D, magnesium, resveratrol or other botanicals for bone-density maintenance and cardiometabolic support.
• Anti-Aging, Brightening and Sensitive-Skin Cosmetics.  Active raw material for topical anti-aging serums, creams, lotions, eye-care, brightening and calming formulations targeting acne-prone and irritated skin.
• Nutricosmetics and Plant-Based Functional Health Products.  Incorporated into ingestible beauty-from-within formulations focused on mature-skin care and photodamage protection, and as a functional additive in plant-based health products.
• Cell and Pharmaceutical Research.  ≥98% HPLC-grade kaempferol supplied for in-vitro and in-vivo pharmacological research, assay development and pharmaceutical intermediate R&D.

Contact Noksoul for Kaempferol Supply

Noksoul supplies kaempferol with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full allergen-cross-contact-control documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.