Luteolin

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Luteolin, a high-purity natural flavone isolated from peanut hull (Arachis hypogaea) through controlled food-grade solvent extraction, column chromatography and recrystallization. Our production workflow isolates and standardizes luteolin, the representative polyhydroxyflavone, delivering consistent ≥98% HPLC material for anti-inflammatory and immune-support supplement formulators, neuro-health and allergy-care product developers, and soothing / anti-redness cosmetic customers worldwide.

Why Choose Noksoul Luteolin

• Natural Polyhydroxyflavone Active.  Luteolin (CAS 491-70-3, 3',4',5,7-tetrahydroxyflavone) is a well-characterized plant flavone with documented antioxidant, anti-inflammatory, anti-allergic and neuro-supportive activity. Sourced from peanut hull, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Controlled Purification Preserving Flavone Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and recrystallization under controlled conditions, preserving the flavone structure and chromophore while removing co-extracted sugars and unrelated impurities.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for luteolin purity (≥98%), alongside profiling of related flavonoid impurities. Multi-analyte documentation gives formulators full traceability to support regulatory filing and label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Luteolin

Botanical Source and Biological Composition

Luteolin (CAS 491-70-3, C15H10O6, MW 286.24 g/mol) is a naturally occurring polyhydroxyflavone (3',4',5,7-tetrahydroxyflavone) accumulated in peanut hull (Arachis hypogaea), and also present in chrysanthemum, honeysuckle, perilla and celery. As a bioactive flavone, luteolin exhibits potent free-radical-scavenging antioxidant activity, well-documented anti-inflammatory activity, anti-allergic / antihistamine effects, and neuro-supportive properties. These multi-mode biological actions underpin its broad use in anti-inflammatory and immune-support nutraceuticals, neuro- and cognitive-health products, and soothing / anti-redness skincare formulations.

Standardized Luteolin vs. Crude Peanut Hull Powder

Crude peanut hull powder contains lutein alongside large amounts of lignocellulose, fibre and other flavonoids; luteolin content varies widely with peanut variety, growing region and processing. Standardized luteolin produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement and cosmetic products.

Production Process

Incoming peanut hull raw material is inspected for botanical identity, initial flavone content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried peanut hull is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated hull undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize flavone components, maximizing luteolin yield while limiting co-extraction of fibre and polysaccharides.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude flavone fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating luteolin from other co-extracted flavonoids, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified luteolin solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; yellow crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for luteolin content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Anti-Inflammatory Activity.  Luteolin is widely used in anti-inflammatory and immune-support formulations, supporting the body's response to everyday inflammatory stress.
• Antioxidant Activity.  Potent free-radical-scavenging antioxidant properties support cellular defence against oxidative stress in daily-health and antioxidant-complex products.
• Anti-Allergic and Respiratory Comfort.  Documented anti-allergic / antihistamine activity supports seasonal allergy and respiratory-comfort supplement positioning.
• Neuro- and Cognitive-Support Research.  Luteolin is widely studied for neuro-supportive and cognitive-health mechanisms, supporting brain-health supplement development.
• Soothing and Anti-Redness Beauty.  In topical skincare, luteolin delivers soothing, anti-redness and antioxidant benefits, making it a desirable active for sensitive-skin and calming formulations.

Applications

• Anti-Inflammatory and Immune-Support Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support immune-support and daily anti-inflammatory supplement positioning.
• Allergy-Care and Respiratory-Comfort Nutraceuticals.  Used in seasonal allergy, upper-airway comfort and anti-allergy supplement blends.
• Neuro- and Cognitive-Health Products.  High-purity luteolin supplied for brain-health, focus and cognitive-support finished goods.
• Soothing and Anti-Redness Cosmetics.  Serves as an active raw material for calming serums, creams and sensitive-skin skincare formulations focused on anti-redness and antioxidant defence.

Contact Noksoul for Luteolin Supply

Noksoul supplies luteolin with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.