Apigenin

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Apigenin, a high-purity natural flavone isolated from chamomile (Matricaria chamomilla) flower and celery (Apium graveolens) through controlled food-grade solvent extraction, column chromatography and recrystallization. Our production workflow isolates and standardizes apigenin, the representative trihydroxyflavone, delivering consistent ≥98% HPLC material for calming and sleep-support supplement formulators, neuro- and cognitive-health product developers, and antioxidant / soothing cosmetic customers worldwide.

Why Choose Noksoul Apigenin

• Natural Trihydroxyflavone Active.  Apigenin (CAS 520-36-5, 4',5,7-trihydroxyflavone) is a well-characterized plant flavone with documented calming / relaxation-support, antioxidant, anti-inflammatory and neuro-supportive activity. Sourced from chamomile and celery, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Controlled Purification Preserving Flavone Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and recrystallization under controlled conditions, preserving the flavone structure and chromophore while removing co-extracted sugars and unrelated impurities.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for apigenin purity (≥98%), alongside profiling of related flavonoid impurities. Multi-analyte documentation gives formulators full traceability to support regulatory filing and label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Apigenin

Botanical Source and Biological Composition

Apigenin (CAS 520-36-5, C15H10O5, MW 270.24 g/mol) is a naturally occurring trihydroxyflavone (4',5,7-trihydroxyflavone) found in chamomile (Matricaria chamomilla) flower, celery (Apium graveolens), parsley and grapefruit. As a bioactive flavone, apigenin is widely recognized for its calming and relaxation-support properties, and also exhibits potent free-radical-scavenging antioxidant activity, anti-inflammatory effects and neuro-supportive properties. These multi-mode biological actions underpin its broad use in stress-relief, sleep-support and neuro-health nutraceuticals, as well as in antioxidant and soothing skincare formulations.

Standardized Apigenin vs. Crude Chamomile Powder

Crude chamomile flower powder contains apigenin mainly in its glycoside form (apigetrin), alongside essential oils, matrix polysaccharides and other flavonoids; free apigenin content varies with flower variety, harvest time and origin. Standardized apigenin produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement and cosmetic products.

Production Process

Incoming chamomile flower / celery raw material is inspected for botanical identity, initial flavone content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried chamomile flower / celery material is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated material undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize flavone components, maximizing apigenin yield while limiting co-extraction of essential oils and pigments.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude flavone fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating apigenin from other co-extracted flavonoids, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified apigenin solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; yellow crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for apigenin content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Calming, Relaxation and Sleep Support.  Apigenin is widely used in stress-relief, relaxation-support and evening / sleep-support nutraceutical formulations.
• Antioxidant Activity.  Potent free-radical-scavenging antioxidant properties support cellular defence against oxidative stress in daily-health and antioxidant-complex products.
• Anti-Inflammatory Activity.  Documented anti-inflammatory activity supports immune-support and general wellness formulations.
• Neuro- and Cognitive-Support Research.  Apigenin is widely studied for neuro-supportive and cognitive-health mechanisms, supporting brain-health supplement development.
• Antioxidant and Soothing Beauty.  In topical skincare, apigenin delivers antioxidant, soothing and UV-defence benefits, making it a desirable active for calming and anti-aging formulations.

Applications

• Stress-Relief, Calming and Sleep-Support Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support relaxation, evening and sleep-support supplement positioning.
• Neuro- and Cognitive-Health Products.  High-purity apigenin supplied for brain-health, focus and cognitive-support finished goods.
• Antioxidant and Anti-Inflammatory Nutraceutical Blends.  Incorporated into general antioxidant complexes and immune-support supplement blends.
• Soothing and Anti-Aging Cosmetics.  Serves as an active raw material for antioxidant serums, creams and calming skincare formulations focused on UV defence and mature-skin care.

Contact Noksoul for Apigenin Supply

Noksoul supplies apigenin with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.