Dihydromyricetin

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Dihydromyricetin (DHM), a high-purity natural flavanonol isolated from the tender stems and leaves of Ampelopsis grossedentata (vine tea) through controlled food-grade solvent extraction, column chromatography and low-temperature recrystallization. Our production workflow isolates and standardizes DHM, the primary bioactive flavanonol of vine tea, delivering consistent ≥98% HPLC material for liver-support and hangover-relief supplement formulators, antioxidant functional-beverage developers, anti-aging cosmetic producers and pharmaceutical intermediate research teams worldwide.

Why Choose Noksoul Dihydromyricetin

• Natural Flavanonol Active.  Dihydromyricetin (CAS 27200-12-0), also called ampelopsin, is a well-characterized flavanonol with documented hepatoprotective, antioxidant, anti-inflammatory, lipid-regulating and antimicrobial activity. Sourced from vine tea, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Gentle Low-Temperature Purification Preserving Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and low-temperature recrystallization. This route avoids thermal degradation that can alter the flavanonol structure and lower antioxidant and hepatoprotective activity.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for DHM purity (≥98%), alongside profiling of related flavonoid impurities. Multi-analyte documentation gives formulators full traceability to support regulatory filing and finished-product label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Dihydromyricetin

Botanical Source and Biological Composition

Dihydromyricetin (CAS 27200-12-0, C15H12O8, MW 320.25 g/mol), also known as ampelopsin, is the principal flavanonol naturally accumulated in the tender stems and leaves of Ampelopsis grossedentata (vine tea). As a potent natural antioxidant, it scavenges free radicals and supports cellular defence against oxidative stress. It is best known for its hepatoprotective and liver-supporting activity, and is widely used in hangover-relief and liver-care supplements. It also exhibits documented anti-inflammatory, lipid-regulating and antimicrobial effects. These multi-mode actions underpin its use in liver-support dietary supplements, antioxidant functional beverages, anti-aging and brightening cosmetics, and pharmaceutical intermediate research.

Standardized DHM vs. Crude Vine Tea Powder

Crude vine tea powder is mechanically milled dried tender stem and leaf containing DHM alongside other flavonoids, polysaccharides, fibre and pigments; DHM content varies with growing region, harvest time and leaf grade. Standardized dihydromyricetin produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement, beverage and cosmetic products.

Production Process

Incoming vine tea (Ampelopsis grossedentata) raw material is inspected for botanical identity, initial DHM content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried vine tea tender stems and leaves are cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated material undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize flavonoid components, maximizing DHM yield while limiting co-extraction of unwanted impurities.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude flavonoid fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating DHM from other co-extracted flavonoids, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified DHM solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for DHM content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Hepatoprotective and Liver-Support Activity.  Dihydromyricetin is widely recognized for liver-support and hangover-relief formulations, helping protect hepatocytes and supporting alcohol-metabolism-related wellness.
• Potent Antioxidant.  Strong free-radical-scavenging and antioxidant activity supports cellular defence against oxidative stress, underpinning its use in anti-aging and daily-health products.
• Anti-Inflammatory Activity.  Documented anti-inflammatory effects support products positioned for inflammation balance and soothing wellness.
• Lipid-Regulating and Antimicrobial Support.  DHM shows potential lipid-metabolism regulatory and antimicrobial activity, broadening its use in functional foods and beverages.
• Anti-Aging and Skin-Care Applications.  Antioxidant properties make DHM a useful active in anti-aging, brightening and daily-protection cosmetic formulations.

Applications

• Liver-Support and Hangover-Relief Dietary Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support liver-care and hangover-relief supplement positioning.
• Antioxidant Functional Beverages and Foods.  Used in antioxidant functional drinks, teas and daily-health functional foods positioned around vine tea and natural flavonol benefits.
• Anti-Aging and Brightening Cosmetics.  High-purity DHM serves as an active raw material for anti-aging serums, creams, essences and daily-protection skin-care products.
• Pharmaceutical Intermediates and Research.  ≥98% HPLC-grade DHM supplied for in-vitro and in-vivo pharmacological research and pharmaceutical intermediate R&D.

Contact Noksoul for Dihydromyricetin Supply

Noksoul supplies dihydromyricetin with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.