Gentiopicroside

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Gentiopicroside, a high-purity natural secoiridoid glycoside isolated from the dried root and rhizome of Gentiana scabra Bunge through controlled food-grade solvent extraction, column chromatography and low-temperature recrystallization. Our production workflow isolates and standardizes gentiopicroside, the primary bioactive bitter glycoside of gentian, delivering consistent ≥98% HPLC material for liver-support and digestive supplement formulators, anti-inflammatory and soothing cosmetic developers, and pharmaceutical intermediate research teams worldwide.

Why Choose Noksoul Gentiopicroside

• Natural Secoiridoid Glycoside Active.  Gentiopicroside (CAS 20831-76-9) is a well-characterized secoiridoid glycoside with documented hepatoprotective, choleretic, anti-inflammatory, analgesic and gastric-secretion-supporting activity. Sourced from Gentiana scabra root, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Gentle Low-Temperature Purification Preserving Glycoside Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and low-temperature recrystallization. This route avoids thermal hydrolysis of the glycosidic bond that would release gentiogenin and lower bioactivity, compared with harsh high-temperature processing.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for gentiopicroside purity (≥98%), alongside profiling of related secoiridoid impurities. Multi-analyte documentation gives formulators full traceability to support regulatory filing and finished-product label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Gentiopicroside

Botanical Source and Biological Composition

Gentiopicroside (CAS 20831-76-9, C16H20O9, MW 356.32 g/mol) is the principal bitter secoiridoid glycoside naturally accumulated in the dried root and rhizome of Gentiana scabra Bunge and related Gentiana species. As a hepatoprotective and choleretic compound, it supports liver function and bile secretion; it also exhibits well-documented anti-inflammatory and analgesic activity, promotes gastric juice secretion as a bitter stomachic, and shows antioxidant effects. These multi-mode actions underpin its use in liver-support and digestive dietary supplements, anti-inflammatory and reactive-skin soothing cosmetics, and pharmaceutical intermediate research.

Standardized Gentiopicroside vs. Crude Gentian Root Powder

Crude gentian root powder is mechanically milled dried root containing gentiopicroside alongside other secoiridoid glycosides, bitter principles, polysaccharides and fibre; gentiopicroside content varies widely with growing region, harvest time and root grade. Standardized gentiopicroside produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement and cosmetic products.

Production Process

Incoming Gentiana scabra root raw material is inspected for botanical identity, initial gentiopicroside content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried gentian root is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated root undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize secoiridoid glycosides, maximizing gentiopicroside yield while limiting co-extraction of unwanted high-molecular-weight impurities.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude glycoside fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating gentiopicroside from other co-extracted glycosides, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified gentiopicroside solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for gentiopicroside content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Hepatoprotective and Choleric Support.  Gentiopicroside is widely used in liver-support and gall-health supplement formulations, helping protect hepatocytes and promote bile secretion.
• Anti-Inflammatory and Analgesic Activity.  Documented anti-inflammatory and analgesic activity supports products positioned for joint comfort, muscle comfort and reactive-skin soothing.
• Bitter Stomachic and Digestive Support.  As a bitter glycoside, gentiopicroside stimulates gastric juice secretion and supports appetite and digestive function, underpinning its traditional use as a bitter tonic.
• Antioxidant and Skin-Soothing Applications.  Antioxidant and anti-inflammatory properties make gentiopicroside a useful active in calming, redness-relief and sensitive-skin cosmetic formulations.
• Pharmaceutical Intermediate and Research.  The defined secoiridoid structure makes high-purity gentiopicroside a reference compound widely used in pharmacology, hepatoprotective research and pharmaceutical intermediate development.

Applications

• Liver-Support and Digestive Dietary Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support liver-protection, choleretic and bitter-tonic supplement positioning.
• Anti-Inflammatory and Joint-Comfort Products.  Used in supplement formulations targeting inflammation balance, joint comfort and muscle comfort, often combined with other botanicals.
• Soothing, Redness-Relief and Sensitive-Skin Cosmetics.  High-purity gentiopicroside serves as an active raw material for calming serums, creams and essences targeting reactive, sensitive and redness-prone skin.
• Pharmaceutical Intermediates and Scientific Research.  ≥98% HPLC-grade gentiopicroside supplied for in-vitro and in-vivo pharmacological research and pharmaceutical intermediate R&D.

Contact Noksoul for Gentiopicroside Supply

Noksoul supplies gentiopicroside with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.