Phlorizin

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Phlorizin, a high-purity natural dihydrochalcone glycoside isolated from apple (Malus domestica) root bark, leaves and fruit peel through controlled food-grade solvent extraction, column chromatography and low-temperature recrystallization. Our production workflow isolates and standardizes phlorizin, the well-known SGLT-inhibiting glycoside, delivering consistent ≥98% HPLC material for blood-sugar and metabolic-support supplement formulators, anti-glycation and anti-aging cosmetic developers, and pharmaceutical research teams worldwide.

Why Choose Noksoul Phlorizin

• Natural Dihydrochalcone Glycoside Active.  Phlorizin (CAS 60-81-1) is a well-characterized dihydrochalcone glycoside and a classic natural inhibitor of sodium-glucose cotransporters (SGLT). Sourced from apple, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Gentle Low-Temperature Purification Preserving Glycoside Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and low-temperature recrystallization. This route avoids thermal hydrolysis of the glycosidic bond that would release phloretin and lower SGLT-inhibiting and anti-glycation activity.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for phlorizin purity (≥98%), alongside profiling of related dihydrochalcone impurities such as phloretin and phloridzin analogues. Multi-analyte documentation gives formulators full traceability to support regulatory filing and label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Phlorizin

Botanical Source and Biological Composition

Phlorizin (CAS 60-81-1, C21H24O10, MW 436.41 g/mol) is the principal dihydrochalcone glycoside naturally accumulated in apple root bark, leaves and fruit peel. As a specific inhibitor of sodium-glucose cotransporters (SGLT1/SGLT2), it blocks renal glucose reabsorption and is a classic research tool for glucose-metabolism and diabetes studies. Beyond its SGLT activity, phlorizin exhibits documented anti-glycation, antioxidant and mild metabolic-support effects, which underpin its use in blood-sugar and weight-management supplements, anti-glycation anti-aging skincare, and pharmaceutical research.

Standardized Phlorizin vs. Crude Apple Extract / Peel Powder

Crude apple peel or root bark powder contains phlorizin alongside other polyphenols, flavonoids, dietary fibre, sugars and pigments; phlorizin content varies widely with apple cultivar, tissue part, harvest and storage. Standardized phlorizin produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement and cosmetic products.

Production Process

Incoming apple raw material (root bark / leaves / peel) is inspected for botanical identity, initial phlorizin content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried apple root bark / leaves / peel is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated material undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize dihydrochalcone glycosides, maximizing phlorizin yield while limiting co-extraction of unwanted impurities.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude glycoside fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating phlorizin from other co-extracted polyphenols, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified phlorizin solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for phlorizin content by HPLC, residual solvents, related-substance profile (incl. phloretin), heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• SGLT Inhibition and Blood-Sugar Support.  Phlorizin is a classic natural SGLT1/SGLT2 inhibitor, widely used in blood-sugar, glucose-metabolism and metabolic-support supplement formulations.
• Anti-Glycation and Anti-Aging Skin Care.  Phlorizin helps inhibit advanced glycation end-product (AGE) formation, supporting anti-glycation and anti-aging skincare targeting mature skin and firmness.
• Antioxidant Activity.  Dihydrochalcone antioxidant activity supports cellular defence against oxidative stress in both supplement and cosmetic formulations.
• Weight and Metabolic Support.  By modulating renal glucose handling, phlorizin supports formulations positioned for metabolic balance and weight management.
• Pharmaceutical and Research Tool.  The defined SGLT-inhibiting mechanism makes high-purity phlorizin a reference compound widely used in glucose-metabolism, diabetes and cardiovascular research.

Applications

• Blood-Sugar and Metabolic-Support Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support glucose-metabolism, weight-management and daily metabolic health positioning.
• Anti-Glycation and Anti-Aging Cosmetics.  High-purity phlorizin serves as an active raw material for anti-glycation serums, creams and essences targeting mature skin, firmness and photodamage.
• Nutricosmetics and Functional Foods.  Incorporated into ingestible beauty-from-within and metabolic-balancing functional products.
• Pharmaceutical Intermediates and Scientific Research.  ≥98% HPLC-grade phlorizin supplied for in-vitro and in-vivo SGLT, glucose-metabolism and diabetes research, and pharmaceutical intermediate R&D.

Contact Noksoul for Phlorizin Supply

Noksoul supplies phlorizin with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.