Daidzein

Description

Noksoul operates a GMP-, ISO- and HACCP-certified production base in the Hongjiang High-tech Zone of Hunan Province, specializing in Daidzein, a high-purity natural isoflavone aglycone isolated from soybean (Glycine max) germ through controlled food-grade solvent extraction, column chromatography and low-temperature recrystallization. Our production workflow isolates and standardizes daidzein, one of the two principal soy isoflavones, delivering consistent ≥98% HPLC material for women's-health and menopause supplement manufacturers, cardiovascular and bone-health formulators, and nutraceutical developers worldwide.

Why Choose Noksoul Daidzein

• Natural Isoflavone Aglycone.  Daidzein (CAS 486-66-8, 4',7-dihydroxyisoflavone) is a well-characterized soy isoflavone aglycone with phytoestrogenic, antioxidant and mild estrogen-receptor-modulating activity. Sourced from soybean germ, it is delivered as a single standardized ≥98% active ingredient, simplifying dose design and label-claim compliance.
• Gentle Low-Temperature Purification Preserving Activity.  Manufacturing applies optimized food-grade solvent extraction, chromatographic separation and low-temperature recrystallization. This route avoids thermal degradation that can alter the isoflavone structure and lower phytoestrogenic activity.
• HPLC-Driven Batch-to-Batch Standardization.  Every production lot is quantified by HPLC for daidzein purity (≥98%), alongside profiling of related isoflavones such as genistein, glycitein and daidzin. Multi-analyte documentation gives formulators full traceability to support regulatory filing and label claims.
• Controlled Impurity and Residual Management.  Our quality system monitors potential cross-contact plant allergens. Each batch is tested for residual solvents in compliance with ICH Q3C guidelines, minimizing processing-related contaminants in the final crystalline powder.
• Heavy-Metal and Microbiological Compliance.  Each lot undergoes ICP-MS heavy-metal screening, full microbiological panel testing and critical safety parameter verification before commercial release, in line with our established ISO / GMP / HACCP quality system.
• Complete Export Documentation.  COA, MSDS, impurity profile certificate, heavy-metal test report and batch-traceability records accompany every shipment. With over two decades of industry expertise, our materials serve customers across Europe, the Americas, Southeast Asia, Japan and South Korea.

What Is Daidzein

Botanical Source and Biological Composition

Daidzein (CAS 486-66-8, C15H10O4, MW 254.24 g/mol) is one of the principal isoflavones naturally accumulated in soybean (Glycine max) germ, and is also found in red clover and Pueraria lobata. As a phytoestrogen, it interacts with human estrogen receptors and delivers mild selective modulating effects on hormone-related pathways, supporting formulations targeting menopausal comfort, hot flashes and post-menopausal bone health. It also exhibits documented antioxidant activity and cardiovascular-supporting properties, and is the precursor metabolite of equol, a highly studied isoflavone metabolite. These multi-mode actions underpin its broad use in women's-health nutraceuticals and cardiovascular-support supplement formulations.

Standardized Daidzein vs. Crude Soy Isoflavone Extract

Crude soy isoflavone extract contains daidzein alongside genistein, glycitein and their respective glycosides (daidzin, genistin, glycitin), proteins and fibre; daidzein content varies with soybean source and extraction process. Standardized daidzein produced via extraction, chromatography and recrystallization is highly enriched to ≥98% by HPLC, enabling precise dose control and reliable batch-to-batch reproducibility for finished supplement products.

Production Process

Incoming soybean germ raw material is inspected for botanical identity, initial isoflavone content, heavy-metal levels and microbiological status prior to manufacturing.

• Raw-Material Pretreatment — Dried soybean germ is cleaned, crushed and screened to remove foreign plant fragments and physical contaminants; botanical identity is confirmed before extraction.
• Food-Grade Solvent Extraction — Pretreated material undergoes circulating food-grade solvent extraction under controlled moderate temperature to solubilize isoflavone components, maximizing daidzein yield while limiting co-extraction of proteins and polysaccharides.
• Concentration and Crude Enrichment — The extraction liquor is vacuum-concentrated at low temperature to recover solvent and obtain an enriched crude isoflavone fraction.
• Column Chromatography Purification — Crude concentrate is loaded onto chromatographic resin for selective adsorption and elution, separating daidzein from other co-extracted isoflavones, sugars and plant-derived impurities.
• Recrystallization for Final Standardization — Chromatography-purified daidzein solution is subjected to controlled recrystallization to achieve the target ≥98% HPLC purity; crystalline solids are isolated by filtration.
• Quality Release and Packaging — Dried powder is assayed for daidzein content by HPLC, residual solvents, related-substance profile, heavy metals, moisture and microbiological safety. Qualified material is packed into double-layer PE inner bags with desiccants, then sealed within light-proof, moisture-barrier fibre drums.

Functional Properties & Benefits

• Women's Hormone Balance and Menopausal Comfort.  Daidzein's phytoestrogen activity supports formulations targeting menopausal comfort, helping to alleviate hot flashes and mood-related discomfort associated with declining endogenous estrogen.
• Bone-Health Support.  As a phytoestrogen, daidzein supports maintenance of healthy bone mineral density, making it a key active for post-menopausal bone-wellness supplement lines.
• Cardiovascular Support.  Daidzein contributes to cardiovascular-support formulations through antioxidant and lipid-metabolism-related activity, supporting vascular and heart-health positioning.
• Antioxidant Activity.  Isoflavone antioxidant activity supports cellular defence against oxidative stress in daily-health and women's-wellness products.
• Equol Precursor and Research.  Daidzein is the precursor of equol, a highly studied isoflavone metabolite, supporting formulations positioned around gut microbiota–isoflavone metabolism.

Applications

• Women's Health and Menopause-Support Supplements.  Supplied for hard capsules, tablets and soft-gel formats. ≥98% HPLC purity and full regulatory documentation support hormone-balance and menopausal-comfort supplement positioning.
• Bone-Health and Post-Menopausal Wellness Products.  Used in bone-density maintenance and age-related bone-health supplement formulations, often combined with calcium and vitamin D.
• Cardiovascular and Daily-Health Nutraceuticals.  Incorporated into cardiovascular-support and general antioxidant women's-health supplement blends.
• Nutraceutical and Functional Food Blends.  High-purity daidzein facilitates uniform blending for isoflavone-focused functional foods and women's-health dietary supplements.

Contact Noksoul for Daidzein Supply

Noksoul supplies daidzein with HPLC-validated ≥98% purity profiles, backed by comprehensive third-party testing and an established ISO / GMP / HACCP quality system. Flexible order sizes are available from laboratory-scale samples to full-container bulk shipments. Custom-purity grades, particle-size specifications and full documentation can be provided on request.

Shipping Method

We offer flexible, reliable shipping options to meet your delivery needs, including:

• Air freight & Sea freight
• International courier services: FedEx, DHL, PostNL, EMS, UPS
• Regional express services: SF Express

 

We will match the most suitable shipping method according to your order volume, delivery address, and urgency, to ensure your goods reach you safely and on schedule.Our Packaging

We offer a range of professional packaging options tailored to different order sizes:

• 1kg per aluminum bag
• 5-10kg per carton
• 25kg per drum

 
For products with special transportation requirements, we provide customized, enhanced packaging solutions. Take Deoxyarbutin as an example: as this ingredient may discolor during transit, we use vacuum-sealed packaging to preserve its quality and appearance.

Our Factory

As a professional plant extract supplier, we implement stringent quality control across every single step of our factory's operations:

• Raw Material Stage: We exercise strict oversight over the planting of raw materials, as well as the sourcing and purchasing processes
• Production Stage: Every detail of the product manufacturing process is standardized and monitored
• Final Stage: We also carry out strict checks for the product packaging procedure

This full-chain quality control ensures that every product we deliver meets the highest standards of quality.